ACTH is used in the differential diagnosis of hypercortisolism and hypocortisolism, e.g. caused by Cushing or Addison disease, and certain tumours. Aldosterone and Renin are typically measured together, and their ratio is the most sensitive means of differentiating primary from secondary causes of hyperaldosteronism. Angiotensin I is involved in hypertension, and NT-ProANP is a marker of heart failure and sepsis.
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