Bones are continuously undergoing a dynamic process of resorption and absorption known as bone metabolism. Signaling pathways on which bone metabolism rely include the action of several hormones, including Osteocalcin, PTH and Vitamin D.
Aggrecan (PG) is being investigated for its role in cartilage deterioration during joint injury, disease, and aging. COMP can be measured for the evaluation of aggressive joint destruction in arthritis. Cathepsin K is a marker of bone resorption.
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